I injured my left wrist/hand 5 1/2 years ago and RSD set in. I was left handed, so I had to learn to be...ehem...right handed. Still hurts to say that lol. Anyway, I learned how to open makeup bottles, put on the makeup, blend it in, put on powder, blush, and eye shadow with one hand. It is most definitely possible. I actually began to learn some of that when I was 15 (a very long time ago) when I injured my whole left side. Back then I even still put on eye liner and mascara. Believe me, it can be done without using your injured hand. I don't worry about it so much anymore, but when I was younger I did. And now that RSD seems to want to go into my face, I will probably be going without makeup more often.