This only proves that you are a normal human being and also increases the likelihood that you have MG. (according to the Modified Alice criteria-see below).

There is a saying that if one person tells you that you are drunk, you can ignore it, but if 10 people do, then you are probably drunk.

This is absolutely non-applicable to sero-negative MG.


No matter how many people (including leading experts) tell you that you do not have MG, you can still have MG.

( I have personally learned that the hard way).

I haven't done a study on that, but I don't think there is any seronegative MG patient that was not told at least once (or possibly numerous times) that he/she have nothing physically wrong with them and only suffer from some ill-defined emotional problems. (or at the most may have very mild/ocular MG).

I use the modified Alice criteria for diagnosing normal tests-seronegative MG:

1. fluctuating muscle weakness.
2. normal test results (including antibodies, SFEMG done by an experienced EMGist)
3. symptoms which are clinically suggestive of MG (or else those tests would not have been done)
4. variable response to mestinon (anything from improvement to worsening or even unpredictable response).
5. no other reasonable alternative diagnosis. (this requires that you have been seen by an MG expert).
5. Some kind of ridiculous psychiatric diagnosis (eg-preocupation with symptoms that effect every aspect of your life, "anxiety" when you have difficulty breathing, "depression" when you have to come to terms with being unable to do what you could easily do before etc.).
6. Abnormal tests which show of some form of muscle weakness but are considered as "false", nonspecific, could be in the normal population etc.

The more criteria you have, the higher your likelihood of having seronegative MG. Having all 6 is a near-definite diagnosis.

Note: I haven't yet done any validation studies on my diagnostic criteria, so please be aware that they may possibly be wrong.

As the medical community has not yet accepted this entity (normal tests seronegative MG) it is always better if your illness is diagnosed as diagnostic SFEMG seronegative MG. Makes life easier for everyone.