I have peripheral neuropathy & inflamatory muscle process in my legs and my left leg is worse.Iwent thru all the blood test and mri of the lumbar spine, left femur the test came back normal execpt my b-12 which was at 275.So the doc at my va recomended I had both nerve & muscle biopsy done which i'm glad i did becauce it showed a problem with the fibers and red blood cells ?? and it has taken us into a new direction of blood tests and i wont know till next month what the results are.The only pain i have in my leg from removing the nerve & muscle is when i cross my left leg.If your doc what to have the biospys done i'd say yes, go for it it my show something or it may not.