Hi Wayner my thoughts are with you, I know exactly how you feel, I to was diagnosed with the skin biopsy, my problems started eight years ago with a tingling in my fingers which progressed to my toes a while later, a couple of years later it had turned into a burning throbbing pain in hands and feet and by this I had a tingling in my face and perineum also a dryness in my mouth which I was tested for sjogrens came back negative, a year and a half ago I started having problems with my bowels and bladder, over time I have been tried on every medication from pregabalin, gabapentin, amytriptiline, lidocaine infusions, mexilitine you name it I have tried it, I either had bad side effects or they didn't work, ten months ago after seeing a professor in London who diagnosed me, his suggestion was to try me on Ivig which I get every three weeks it helps a bit it brings my pain to a bearable level although it dips just after two weeks and then it is back to a lot of pain and sleepless night until the next infusion, as you say it dramatically affects your life, I am so glad I found this site as there are so many helpfull people with a lot of knowledge,I have found out more about my condition from here than I have from my neurologist it has given me an insight into questions I will be asking him in a couple of weeks time. I am glad you are getting significant relief from your meds. Take Care Marie