I am sorry to hear that CtenaLouise I too just switched to cymbalta from effexor. I am just now making the transition, so on half effexor and half cymbalta. I have lots of pain and depression, so I asked the doctor if I could be switched to cymbalta. I will let you know how I react. Hopefully, my cells are cymbalta friendly I will let you know. Have you tried effexor?