Going by the amount of cucumin tablets he has taken I would guess he has taken them for about 4 months.We have a problem in that there are so many variables to say why he seems to be a little better.He takes 500mg of cucumin with 3mg of bioperine.BUT combined with this he takes a supplement called Alpha from Higher Nature which containsALC/ALA.Additionally with this he takes their high dose anti oxidant tablets and two cod liver oil capsules.Last thing at night he takes I teaspoon of cough medicine containing D.M.His only prescibed medication is Requip ;4mg 4 mg 4mg and 1 mg plus propranol for the tremor.I must admit that we thought it was the D.M that caused the improvement as he is sleeping so much better with no early morning wakefulness.It may be that he is not now fighting off winter ills .I do not know but it did my heart good to see him stride across the car park today .I must remember that it is early days yet and not very far down the road as he has been diagnosed just under 3 years.He was a marathon runner but can still use the treadmill/cross trainer and still exercises vigourously for about 40 minutes most days and plays his squeeze boxes about 2 hours a day.Interestingly as he plays by ear he says the music overcomes the P.D.I have rambled on a bit but I think you need the full picture.I the cause of science he should drop all supplements except one but he is so well I am loathed to advise that. Thanks for your interest and help.