Count me in the "Mestinon doesn't do much" crowd. I am subject to spells of intense weakness that last about an hour. Mestinon does nothing to prevent or abort them. In addition, I have general mild weakness throughout the day. Mestinon seems to help this somewhat--not really enough that I'm totally convinced it's working--but if I take it regularly, after about a week my left eye hurts. None of my doctors think this makes sense, but it's very regular. So I take 30mg. now and then, like if I'm going somewhere tiring.

As for other side-effects, I have no stomach upset or diarrhea. While I was taking higher doses (60mg. every three hours) I used to get painless muscle twitches and my mouth would water.

I am still doing much better on the Imuran, though I went on a camping trip (just two days) with my family, and that set me back. But I seem to be snapping back to the pre-camping state. I tire easily, and feel the weakness in my arms and neck, but no more of those intense spells.

Abby