To me, tiredness and muscle fatigue seem like two differant things. I think.

If you are taking your Mestinon as prescribed and you get out of bed one day and able to walk around the block and then the next day you know you are not going to make it so you get three houses away so you turn around and go home is that because your muscles are more tired or fatigued?

If you are sitting in your chair and you go into crisis, is that your diaphragm gotten tired or fatiqued?

I know Webster would define them the same but to us it might be called something besides tiredness or muscle fatigue when our muscles just shut down. I wish I knew.

scrubbs