Mestinon didn't do anything for me- except cause me to go into a crisis when I was accidentally overdosed by a very well meaning, but in-over-his-head neurologist. My new neurologist has explained that it is important to know if you are you are antibody+ and the type of antibody+ because if you are NOT than Mestinon/IVIG/Plasmapheresis may not always work- and only certain treatments work for certain positive profiles. (I am negative for all three and currently giving IVIG a last shot anyway).

Scrubbs-you brought up a very interesting point about the diaphragm. I always associate my limbs/eye muscles with being fatigued- AKA no big deal- I just overdid it and I can push through it with a good night's sleep and by taking it easy. Recently though I think some of my "involuntary muscles" have been weak- and more than just the typical bulbar muscles, which are always pretty crummy.

My appetite has been really bad and my GI told me he thinks my stomach is so weak that it cannot properly digest hence it takes me much longer to digest and I am losing weight and not hungry (I can feel like I overate for 12-14 hours after a small meal). I am also down to 105lbs (I'm 5'2"). Also my wonderful nurse who administers the IVIG has noticed that when we infuse in the morning my blood pressure is pretty normal but every time we infuse at night it is very low. She is beginning to believe that my heart might not be pumping as well at night and that may be adding to my general feeling of being physically exhausted.

Has anyone experienced things like this?