When I was taken off of Imuran it was because my lab work was not good. My neurologist advised me to stop the drug and did not taper me off of it. However, I wasn't on a real high dose.

How long have you been taking Imuran? Has it been effective with decreasing/eliminating your symptoms? Perhaps your doctor wants you to decrease slowly as a trial to see how you do off of the drug.

I'm not sure about Imuran, but do know that very small decreases in my Prednisone dose have resulted in an increase in my symptoms. My neurologist doesn't seem to think that is unusual.

I hope you're able to get some answers.

Cate