Hi Debbie and welcome.

My first DMD was Avonex. It was really rough at first. I had shaking chills so bad tht I couldn't unclench myself to get aspirin & water and more blankets. I called the doctor the next day.

I was started on a protocol of aspirin 2 hours before the 6PM shot and then again at bedtime w benedryl. I could have the aspirin during the night if it had been 4 hours. If not I could alternate w Tylenol. That worked out OK. I still had the flu symptoms but never the shaking chills again.

I was on it for 5 years and it worked for me. I did start to hate that needle even though it was once a week. When I came up w 1 new lesion on an MRI, we used the opportunity to switch to Rebif.

We are all different. You just have to pick what will work w your schedule and see what happens.

ANN