Detrol and Vesicare did not wow me with my kind of Urine incontinence but Oxtbutynin (increase capacity of bladder, not decreases spasms which was not my problem) really worked. Everyone is so different. Provigil had an adverse effect on me (opposite) and made me more tired, Amantadine helps some. Hydro/Acetamine does nothing but Valium knocks me off my feet into unconsciousness!