*edit*

What the researchers found was that MS patients have reduced levels of noradrenaline. Noradrenaline is derived from dopamine.

Erika~The information you posted on supplementation is one reason why it is important to understand the entire disease process. Just because you lack something doesn't mean it is a good idea to take additional in supplement form. What if you cannot properly metabolize the nutrient and that is the reason you lack it? For instance, the lack of DNase1 in lupus led to unbroken down protein particles and DNA in a lupus patients bloodstream. The immune system targets these protein particles and DNA because they are foreign. Much like a celiac patient is unable to digest the protein gluten and the immune system is reacting to the unbroken down gluten fragments. Would it be a good idea for a celiac patient to take isolated portions of gluten into their bodies? Here is something I have written previously on this topic.

"A word of caution: The lack of amino acids found in CFS and fibromyalgia
are a result of the inability to digest dietary proteins. If you are unable
to digest proteins, you would also be unable to properly metabolize
the amino acids of which proteins are comprised. The previous study
“Cobalamin Malabsorption Due to Nondegration of R Proteins in
the Human Intestine” showed that pancreatic enzymes are necessary to
degrade R proteins (amino acids). The inability to digest proteins and
amino acids is what led to the unbroken down bits of protein and DNA
in the bloodstreams of lupus patients. The immune system targets these
proteins and forms immune complexes, which then become lodged in
healthy organs and tissues. Taking additional amino acids in supplement
form would lead to an increased risk of disease. This is evident in the
findings from the study entitled “Intermediary Metabolism of Phenylalanine
and Tyrosine in Diffuse Collagen Diseases” (Nishimura, 1959). When
lupus patients were given supplements of tyrosine and phenylalanine, the
supplements “unfailingly aggravated both clinical signs and laboratory data
of collagen disease.”

Hey daisy.girl~I am trying to explain the entire disease process by taking each symptom and tracing it back to these missing enzymes as evidence that this is the source of MS. So that really is it in a nutshell; missing pancreatic enzymes that break down dietary proteins and DNA are lacking in MS and in other autoimmune diseases and this is what leads to all of the symptoms and scientific findings in these diseases. How do you fix it? By restoring these enzymes through diet, healing your GI tract, destroying pathogenic bacteria, replenishing beneficial bacteria, intrinsic factor, HCI, and avoiding any and all things that deplete or harm you entire GI tract.

Hi Mariel~We can trace the buildup of porphyrin directly back to PEDD. Again, here is something I have written previously on this.

"The body makes heme mostly in the bone marrow and liver. The process
of making heme is called the heme biosynthetic pathway. Each step of
the process is controlled by one of eight enzymes. If any one of the eight
enzymes is deficient, the pathway is disrupted. As a result, porphyrin or
its chemical precursors, may build up in body tissues and cause illness
(National Institutes of Health, 2008).
Porphyrin can accumulate in the skin and cause photosensitivity. Exposure
to the sunlight may cause symptoms such as redness, rash, itching, burning,
blistering, and swelling. Once triggered, an episode can escalate and cause
even more toxic porphyrin to build up in the tissues, leading to even more
serious illness.
The first component in the heme pathway is succinyl-CoA. Vitamin
B12 serves as a cofactor for methylmalonyl-CoA mutase which converts
methylmalonyl-CoA to succinyl-CoA. Therefore, a lack of vitamin B12
would lead to a failure in the entire heme pathway."

I wanted to go through the missing neurotransmitters first and then show why MS patients are unable to metabolize vitamin B12.