Until I added Comtan, I was at 1200 mg a day. I don't freak out about it anymore. I have a three year old who needs me, so couldn't care less on the amount. I am lucky in that I don't have much dsykinesia. I am now at 800-900 on a good day. Some days I am right up there with Madamlash. I cannot tolerate more than the bare minimum agonists- what is the point if throw up my dosage each morning? I do take the ER of Requip but find it is very easy to over medicate and not even know it. My liver will probably give up on me some day, but oh well.

I am asymptomatic when on for the most part and prefer that to the yoyo effect on on - off. Also, I started taking Sinemet three times daily but despite also being on Mirapex, I never saw longer than a three hour benefit from the gate.

Bear in mind, prior to add on of carbidopa, people took and tolerated up to 9000 mg a day!

We all have different metabolisms....

Laura