Quote:
Originally Posted by glenntaj
--to find out why the B6 levels were so high (especially if you are not supplementing).
B6 "intoxication" can cause neuropathy symptoms in some cases. Mrs. D has accumulated a lot of abstracts on our supplement "sticky" that seems to point to this often having to do with a genetic mutation that makes some people unable to methylate pyridoxine (the "raw" from of B6), which causes an accumulation of unused B6 in the body over time and may lead to symptoms, though this generally happens only to those who take a lot of extra B6. Curiously, this does not seem to happen to those who take the already methylated P-5-P form of the vitamin.
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Thanks for the links, I checked them out, it appears from WUSTL (my neuro verified this yesterday) that for elevated B6 to be of concern it would have to be 10x upper limit of normal (Normal 40–120 µg/l), and mine was 189...so he pretty much said it was probably from foods I have been eating as it was suppose to be drawn after fasting (which it was not)...
On a side note, had my follow up with Dr. Freeman @ Beth Israel who is suppose to be a world renowned expert in autonomic dysfunction/SFN...
He said all relevent tests have been done and that I am one of the idiopathic..I started listed off testing for various heriditary, AB's, toxins, etc. etc. and he said I just dont have the symptoms, I've had 18 neuro evals by 7 different neuros and everyone has been perfect (all sensation, gait, motor function, EMG, etc.) as well as 2 autonomic tests which the cardiovagal, adrenergic, and sudomotor evauls were all normal both times...
Only abnormality was the auxiliary evaul showed "mild" POTS with no resulting hypotension and of course the skin biopsy showing "mild" SFN @ the thigh..
Easy for him to say when I feel so awful, but he said he is almost 100% certain (due to my age, general health, onset, symptoms, etc.) that is is all due to an infection (maybe EBV, cytomeglovirus, etc. all of which I have raised IGG for) that I came down with in Feb.