So, the spots wear I place my Clonidine patches seem to be turning bright red when I'm flared even a few weeks after removal, in an exact rectangle matching placement. I do rotate locations, but they're all along the nerve line of my worst effected area. This seems to be a new problem after over a few years of wearing them.

Anyone else? I'm almost thinking it's less a reaction to the med, and more the patch itself. I don't wear clothing that ever touches that area.