Some chemotherapeutic agents are being used with some success. Oral imuran, etc. IV rituxan (monoclonal antiabody). Both of the above have helped me. I was on oxygen 24/7 due to lupus and now only on at night. Still have loads of problems tho. If I was told stem cell transplant had a 50% chance of curing me I'd go for it. When I had lymphoma due to lupus in 2001 I had a 50% chance and I made it. I decided make it or not it was my only reasonable choice and I'd do it again because the type of autoimmune problems I have now are just as dangerous. nancy