Hey Sally~I think the evidence will show it is the depletion of these enzymes that leads to autoimmune disease. For instance, here is a study on the development of RA and lupus after exposure to insecticides. Insecticides are poisons. The very dictionary definition of a poison is that it kills enzymes.

RA and Lupus with increased exposure to insecticides. Spraying for
bugs could increase autoimmune disease risk – Press Release
Latimer, E. 2009. American College of Rheumatology.

The following abstract shows the association between the first outbreak
of chronic fatigue syndrome and fluoride in the drinking water. As the abstract confirms,
fluoride is a potent enzyme poison due to its affinity towards trace minerals.
From the Abstract Chronic Fatigue, Fluoride and Heavy Metals
Phelps, J.E. 2005.
Latimer, E. 2009. American College of Rheumatology.

The top 3 drugs that are known to induce lupus are all "enzyme blockers." Here is some information from my book.

Q: Why do some drugs cause lupus?
A: Certain medications may cause lupus. This is called drug-induced lupus. There are
38 known medications that can cause drug-induced lupus. Most cases, however, are
associated with procainamide (Pronesty), hydralazine (Apresoline), and quinidine
(Quinaglute). All three of these drugs are enzyme inhibitors.

We will be demonstrating "cause and effect" throughout this entire process. For instance, it is low levels of uric acid that lead to gout, not the other way around.