I'm seronegative, though my neurologist is confident that I have MG. My twitching/fasciculations occur mostly in my legs and seem to be more prominent when my legs are fatigued. My neurologist can't really explain why it happens but thinks that it is related to the myasthenia.

Mestinon will make the twitching worse; my twitching started about a year after my other symptoms (double vision, weakness) started. I didn't start taking mestinon until about 6 years after the twitching started.

Cate