Yes, the glia are also involved with opiate tolerance, and the formation of new pain receptors.
I am going to try the low dose Benadryl myself. I use it at bedtime in regular doses, and it seems to help my feet when they are acting up.
There ARE histamine receptors in the brain. So it is worth a try.
5mg is below the threshold for side effects. Apparently there are none at this dose.
Mast cells are allergic histamine release cells. Keep that in mind, also.
http://en.wikipedia.org/wiki/Mast_cell
__________________
All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
************************************
.
Weezie looking at petunias 8.25.2017
****************************
These forums are for mutual support and information sharing only. The forums are not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. Always consult your doctor before trying anything you read here.