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Old 09-08-2012, 07:30 AM
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mrsD mrsD is offline
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Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
Lightbulb

The --caine anesthetics are derived chemically from cocaine, historically. But Lidocaine and Benzocaine do not have the CNS euphoria characteristics.

They work by blocking sodium channels in nerve membranes. The flow of sodium into the nerve cell and potassium out, is what propagates the biochemical electrical signal that nerves send.

When sodium channels are blocked, the nerve cannot communicate pain signals for a short time. None of them are long lasting. In patch form, Lidocaine called Lidoderm, releases lidocaine over a period of 12 hours, and therefore lasts longer because of the patch dynamics.
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