I'm quite alarmed at the hype coming from THERACYCLE, I get an email a week from them promoting their device and now i can even talk to people who have tried it.

i'm anxious to see the results from roberts next trial, anyone know if it has started?

the benefit appears to be transient, it goes away if you stop cycling. but according to alberts study lasted weeks after the participants stopped. so either those neurotrophic factors have a long half life or there were temporary changes at the DNA level to produce these factors or do something that temporarily changed the dopamine system, either create more dopamine, produce a few more dopamine cells from stem cells, increase dopamine receptors? seems end game would be find drugs/gene therapy that could do the same thing as vigorous excercise.