Originally Posted by fmichael

By example, see, “Pathophysiology of Complex Regional Pain Syndrome,” Robert J. Schwartzman, et al, Expert Review Neurotherapeutics, 2006 May 6(5):669-81, . . . at 674-75:

The recent ischemia-reperfusion model presented by Coderre and collegues is comparible with many of the signs of autonomic dysfunction and pain noted in CRPS I. Prolonged hind-limb ischemia in the art followed by reperfusion causes:

- A hyperemic and warm extremity in 4 g that evolves into a dry and shiny extremity within 4 h;
- Pinprick hyperalgesia, cold and warm mechanical allodynia that lasts up to 4 weeks;
- Contraleteral damage.

The ischemia may sensitize and activate deep tissue noceptors of muscle joints and bones which, to date, has not been explained and, as noted above, is very important in CRPS.