Quote:
Originally Posted by Conductor71
This is by the same guy who offers amino acid treatments in conjunction with levodopa therapy.
It is interesting given no one knows how DBS works and that electo convulsive therapy and magnetic resonators work for us. Here is perhaps why?
The etiology of chronic problems is not low concentrations of monoamines that need to be returned to normal as predicted by the monoamine hypothesis; it is concentrations that are normal but not high enough to compensate for postsynaptic neuronal damage. Addressing this electrical defect properly requires the system to be placed into the competitive inhibition state in order to be able to increase monoamine levels to above normal to reach the threshold level needed to establish the adequate electrical flow required.
This paper does try to sell his neurotransmitter balance based therapy...still this seems entirely plausible to me. Anyone else?
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282597/
Laura |
voltage-gated ion channels and dopamine dispersal, Iwas seeing in my mind's eye a slow-moving, rather boring, mental movie in which several molecules of dopamine were made , somehow placed in some kind of conveyor system and dropped off at a transfer point where they waited until a sufficient electrical charge was attained to open the door to let them out. When the door opened they would, much like paratroopers, leap out into the intrastatial fluid and floa around until they came across an unfilled receptor site.
Suddenly, without warning or forethought on my part, the picture changed to an action packed adventure in which theere w er a multitude of mitchondria working furiously to make a quota of dopamine molecules that were wissked away without delay to many pressurized chambers which opened on a predetermined schedule spewing the molecules so fiercley from the opened doors that they took on the appearance of sizzler fire works. I had just had my FIRST 3-dimensional thought. I was so impressed that I did a se arch to finnd out how many mitochondria there are in a neuron. There are possibly a thousand. That model made much more sense than did the one that slowly left it all to chance.
http://https://docs.google.com/viewe...eoJjDQ_LVXsIPA
Here is a site that discusses the quantum mechanics of voltage-gated ion channels. I think we need a new brain model.
michael