I merely posted the paper and you and others may reject it's conclusions. As for me, I did not present a critique to the paper although I am generally skeptical to all research. The wording of my title is derived directly from the paper discussion section which says:
"Our study is the first to demonstrate that a simple water extract of Mucuna pruriens endocarp powder with no additives has a superior effect to the combination of MPE+BZ on parkinsonism and that MPE alone is superior to LD alone or LD+BZ combinational therapy in terms of efficacy of ameliorating parkinsonism with dramatically reduced risk for DID"
Thank you any way for reading the paper and presenting a critical analysis of its claims !
Imad
Quote:
Originally Posted by soccertese
i think your title is very misleading btw, the experiment involved monkeys, not humans, they used a mucana extract THAT ONLY A LAB COULD PRODUCE EASILY and in reading the paper it appeared sinemet produced better UPDRS(?) scores,
"Effects of MPWE and LD. MPEP was
dissolved in sterile water and thoroughly mixed for 30–
45 mins. The mixture was then centrifuged at 14,000–15,000
RPM for 15–20 mins, and the supernatant was extracted
and filtered. The MPWE solution was then stored in sterile
containers at 4◦C. Prior to administration, the MPWE
solution was briefly agitated and dispensed orally. The dosage
concentration of MPWE was based on 4-5% of natural
occurring LD in MPEP such that the MPWE solution had
approximately 24mg LD per mL.
]
I also have to wonder about the following in possibly causing dyskinesias by possibly producing a very quick increase in l-dopa:
"When
compliance was an issue with oral LD+CD, animals received
systemic injections of LD at the equivalent optimal doses
of oral LD (LD methyl ester with benserazide (BZ))."
"3.1. MPEP and LD Effects on Parkinsonism and Basal Ganglia
Electrophysiology. mUPDRS scores on placebo were 15.6 ±
2.6 and decreased to 8.0 ± 1.6 with MPEP alone, 7.7 ± 1.5
with MPEP+CD, and 4.5 ± 1.1 with LD+CD, optimal doses
(Figure 1). These doses caused no observable adverse effects.
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