I too got severe depression on prednisone and IVSM. Steroids can do that to you. I'll second what Ginnie said, get off them if you can! There maybe something else out there that can help keep your flares away. Im constantly amazed at all these meds out there that help one problem, but create 5 more problems. Depression is the worst. Ive had it for too many years to count. It comes with chronic illness' I believe. Who wouldnt be depressed going thru and coping with what we have. I too have been down the "I want to end it all" alley. I was dx at 22 with 2 wee ones at home. Its a lifetime of crap, but always remember you're not alone. We are all here for you. The support and guidance given here is far more than I ever expected. Folks here are truely a God send. There's alot of help out there for you before you really hit rock bottom. 800 numbers galor, and counselors at churches, hospitals, local community college, (they normally have students in their final year from the psychology dept) etc. Never give up. There's always something better around the corner for you, you just have to take that next step to see it. Never give up, never surrender!!