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Originally Posted by StephC
I get it a lot isnt understood about nmj but has it been determined that living with MG without treatment (undiagnosed) for many years causes damage that cannot be repaired? If yes is damage due to "pushing through" symptoms and doing ore than should or due to lack of medication to assist or both?
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The answer to your first question-No, there is no clear data which show that.
I believe (from the limited data there is) that it is more likely that the severity of the illness is determined by its nature to begin with. So, some patients will have a relatively mild illness which will never progress, whereas others will have a more progressive course. It is not clear if response or lack of response to treatment is also predetermined.
As to your second question, I think that it can cause damage.
In fact even trained and healthy athletes have some damage when they exceed their abilities. Trained marathon runners do not run faster than what they can with 70% of their VO2 max.