I came across your post in regard to metoforim and myasthenia. Due to taking prednisone for 5 years now with dosage from 5mg-60mg per day I was recently diagnosed with diabetes. The doctor put me on metorforim 500 mg in am and 500 mg in pm. Most of the time I skip the pm dosage. Shortly after starting metorfim my myasthenia got worse. My neurologist upped my prednisone to 60 mg daily. In the morning I feel good until I take the metorforim. What negative effects are you having from the metorfim?