Most of the people who discontinue Metformin do so because of the gastrointestinal side effects. I personally found them unbearable. Constant cramping and diarrhea.
The other thing metformin does is to deplete Vit B12... but this takes some time, and is not an instant effect.
I'd get a serum B12 run to see if you are low. Being weak and tired can be one sign of low B12.
Long term use of prednisone will deplete many things. Magnesium, zinc, and potassium, calcium and selenium.
Also folate, Vit C and Vit D.
All these nutrients may be affected by long term prednisone use.
I could not find any papers on metformin and myasthenia.
Metformin does not dramatically lower blood sugar as a rule. It might
be a good idea to get a glucometer and measure your blood sugar several times a day to see what it is doing.
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All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
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Weezie looking at petunias 8.25.2017
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