I have had now 5 IPIR's with copaxone. Just had my last one saturday. Injection was fine, but 50 seconds later, my hands turned beat red and felt like they were swollen and on fire, my face and ears did the same thing, and my throat felt like it was closing and such an intense stabbing sharp pain in my lower back. My lower leg also felt like it was on fire. Called SS and they said I had all the symptoms of IPIR and not to take any more shots until I talk to my doc. Well, thats enough for me. This was the most severe and it scared the daylights out of me, so, Im done. No more. Its now Monday, and Im finally feeling a bit better. Took along time for my body to get over that shot. My throat still feels a bit closed off, but not as bad. I dont really care what my neuro has to say about it, Im done. I'll ask for LDN, but none of the dmd's. Sometimes I wonder if this is all worth it. MS is going to do what its going to do no matter what I do. All these chemicals I put into my body, could they be causing more harm than good???