Hi KittyLady,
I am sorry your experience with meds has not been very helpful to you.

I don't have a formal diagnosis of MS, yet have had many co-occurring diagnoses of the central and peripheral nervous systems. All very painful. Lots of spasms, weakness, severe fatigue, etc. Severe disability. (All in all, it appears to look more and more like MS. My primary Neurologist strongly feels I have MS in addition to other neurological issues, yet... we will see.)

We have tried so many meds and combinations of meds for the past 30 years!
I cannot tolerate more than 90% of all of the meds! I just cannot! It's incredibly frustrating! I have all kinds of serious reactions to most meds, which make me worse, not better. Not helpful.

I will be starting with a Physiatrist soon and hope this helps me some, even a little. I cannot find anyone, yet, interested in prescribing LDN.

It can be such a long road sometimes.
My heart goes out to you, KittyLady!
I hope you find some truly significant relief, soon!