It is true that the disease itself does not come with pain. However, if I try to use my muscles longer than I should, then I have pain which I liken to overusing them. As an example, my legs are really starting to become weak and last week, I walked around WalMart (I usually use the carts). The next day, my legs felt like I had climbed a mountain. All the muscles were sore like they had been overstretched. Hope this helps.