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ex-Member
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Join Date: Sep 2006
Posts: 110
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ex-Member
Join Date: Sep 2006
Posts: 110
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Dopamine both reduces excessive muscle contraction AND stimulates the emotions. So it is to be expected that there is an association between the muscular symptoms of Parkinson's Disease and depression.
The Rotterdam study (below) also showed that subjective complaints of stiffness, tremors, and imbalance preceded Parkinson's Disease.
So if somebody is prone to depression, stiffness in the muscles, and has experienced tremor and imbalance, then it looks like Parkinson's Disease is on its way.
For every person who has been diagnosed with Parkinson's Disease there are probably over a hundred who are not that far from it. For them, its either on its way, or it never quite gets bad enough for them to cross the diagnosis barrier.
Archives of Neurology [2006] 63 (3) : 362-365
(de Lau LM, Koudstaal PJ, Hofman A, Breteler MM.)
Subjective complaints precede Parkinson disease: the rotterdam study.
BACKGROUND: Neuronal degeneration and dopamine loss in the preclinical phase of Parkinson disease may produce subtle complaints before clinically recognizable symptoms emerge.
OBJECTIVE: To examine whether subjective complaints of stiffness, slowness, tremors, or postural imbalance in persons without clinical signs of parkinsonism are related to an increased risk of future Parkinson disease.
DESIGN: Population-based cohort study. We recorded subjective complaints of stiffness, slowness of movement, tremors, falling, or a feeling of imbalance in a standardized interview of 6038 participants without dementia in whom no parkinsonian signs were found on physical examination at baseline, and we studied them prospectively for the occurrence of incident Parkinson disease.
SETTING: General population.
PARTICIPANTS: A total of 6038 participants who were free of dementia and parkinsonian signs. MAIN
OUTCOME MEASURES: Incident Parkinson disease. Participants were examined in person both at baseline (January 1990-June 1993) and at 2 follow-up visits (September 1993-December 1994 and April 1997-December 1999), and the cohort was continuously monitored through computerized linkage of the study database to general practitioners' medical records. We analyzed the data using Cox proportional hazards regression models.
RESULTS: Participants who reported stiffness, tremors, or imbalance at baseline had a significantly increased risk of developing Parkinson disease during follow-up (for stiffness, hazard ratio, 2.11; 95% confidence interval, 1.25-3.55; P = .005; for tremors, hazard ratio, 2.09; 95% confidence interval, 1.12-3.90; P = .002; and for imbalance, hazard ratio, 3.47; 95% confidence interval, 1.69-7.00; P = .001).
CONCLUSIONS: Subjective complaints of stiffness, tremors, and imbalance are associated with an increased risk of future Parkinson disease and may reflect early effects of dopamine shortage, even when standard neurological testing cannot yet demonstrate any motor symptoms.
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