That's interesting, it does say that levothyroxine (one of the generics for Synthroid) and Nexium can be taken at the same time. My sister (a pharmicist) prefers to take her Synthroid before bed, though her doctor would prefer (for whatever reason) that she take it in the morning. As you probably know, blood levels of your thyroid hormone matter, so take the info to your doctor to discuss, and get your TSH level checked at the recommended period of time after you make the change.