I have actually been on prednisone now for a month and I expected weight gain and was warned about it. With little or no exercise I figured it was part of what I would have to deal with. Instead I have lost 10 to 12 pounds in the past month and I am wondering if anyone else has seen similar weight loss. I am now taking 80mg every other day. Plus 60mg of mestinon 4 to 5 times a day.