I started taking r lipoic acid about 7 days ago. I took 50mg for 2 days and did not notice any side effects so upped it to 100mg. I can not believe that I am already feeling a significant decrease in the feet burning at night. I had spoken to my neurologist last month regarding the r ipocic acid and she said it's been around a long time but does not work. This last visit she did a compound cream for my feet but no relief. I have already been through all the traditional PN meds and refuse to put up with the brain fog and other side effects. I also take B12 and B6. The B6 helps with the electric shocks.: