I'm not in the habit of using forums so I have not checked this since posting a couple days ago. I appreciate all the replies and will try to respond to many of the posts.

Rick has been on 4.5 mg of LDN for 2 years and when he first went on, he was able to go from two sinement a day down to one with no loss of function so we felt it had some symptomatic relief for him. He recently has now gone up to 2 sinemet a day (along with 5mg of selegeline that he has been on for some time) after he did a trial of rasageline. In order to go on that, his neuro said to drop the selegeline for 2 weeks then go on the rasageline. Well, the rasageline never really seemed to work for him (tried it for 6 weeks) so he went back to the selegeline with the sinement. However, then it seemed he need 2 sinemet a day and also noticed that now he was really experiencing being on and off with the sinemt.

Its hard to know if the LDN is working but it seems to be helping. I'd say he has definitly had less progression over the last two years while on LDN than he did the first year and a half without it.

Right from the start, he has been on Co-Q10. We also started going to a naturopathic physician early on and he started taking numerous supplements and did 11 sessions of IV chelation therapy plus oral chelation. That did reduce his levels of heavy metals. He takes numerous supplements including fish oil; muti-vitamins and minerals; a dopamine support supplement called balance D from Neuro Sciences; a "Mitochonrial energy optimizer" from LE that contains acetyl-l-carnitine, rhodiola, R-lipoic acid, etc; cucurmin; melatonin; milk thistle; etc. Even before he started the PD meds, we saw a lessening of some symptoms (swallowing difficulty, muscle cramps, slight drooling) from these treatments. Also, he was able to go off his blood pressure medication that he had been on for about 10 years and his BP has stayed just fine without it.

He also has done some accupuncture and does chiropractic.

I see in another thread, discussion of loss of smell. Rick lost had lost his smell by 23 years ago, when our daughter was born. I thought perhaps he was purposely trying to avoid his fatherly duty to share in the diaper changing work, but by that time he really couldn't smell the dirty diapers. That was when we first realized that his sense of smell, which had been better than mine 5 years earlier when we were married, was now pretty much gone. Another 20 years passed til he was diagnosed with PD.

As far as the farming exposures, Rick was exposed to insecticides in years past as he was the main person who would spray the cows with fly spray (including some organo-phosphates) before we were organic. He also certainly could have been exposed to hay and grain dust, although that exposure has been minimal in the last almost 20 years as we now use little dry hay or dry grain that he would be exposed to.