Anniekins,
some people have paradoxical reactions to medications, ie, the opposite of the expected result. Benadryl is a good example. It is supposed to make you sleepy, but for some, it makes them hyper.

If you are having difficulty sleeping and had not before adding the second medication, call your Dr. and tell him what you are experiencing. Lack of sleep just makes pain worse, as I'm sure you know, and your Dr. should be told.
I hope things get better for you soon.

Sam