It is pretty cool. Yet, what I don't get is how people in such good physical shape can get sick with this in the first place when it looks so neuroprotective after the fact? On the one hand, we are led to believe that exercise wards off neuro decline and effects of aging, yet even athletes do not necessarily seem better equipped to avoid PD. How is it the that the exercise is not enough to ward off disease onset, but powerful enough to function like levodopa to reduce symptoms?

I am wondering if exercise, which is beneficial for neurotransmitter homeostasis and/or generation, works with our compensatory system somehow. I still find it amazing that our brain compensates long as it does in the first place. Maybe exercise allows us to tap back into that somehow?

I also think that what he said about making opposite movements of PD (BIG training) can help us re-circuit our faulty wiring? Perhaps, most amazing at all is how long has it been the norm that stroke victims can regain movement or function and we are now just "discovering" this on a clinical level with PD?