For those of you who don’t know me on the forums, I am a 40 years old and have been dealing with some type of Idiopathic Neuropathy for the past two years. I’ve been trying a lot of different meds, vitamins, and tests to figure out what’s going on with me. Aside from a lumbar puncture that showed a slight protein elevation all other tests came up empty. Funny thing was I always felt tired my whole life, lack of energy. I had Mono and EPV between 18-28 years old. In my 30’s I exercised, ate healthy and felt great. Never got sick or felt tired. At around 35, I started to eat junk again but never got sick or felt run down It seemed eating health jumpstarted my immune system. By 36 I had LPR reflux and started on Nexium (PPI). At 38 years old is when it all happened. Started with tightness in throat for 6 months, then burning in chest for 9 months and then burning moved to my back. It sucks because my upper back, lower neck area is sensitive to touch (Allodynia) and its causes a lot of pain. I don’t have any motor or autonomic issues, strictly sensory. I decided to get a 23andme test kit and uploaded my data to
http://geneticgenie.org/methylation-analysis/ and gave me the attached readings.
COM V158 +/+ Says not to take a lot of Methyl supplements
MTHFR C667T +/- and MTHFR A1298C +/-Both C667T and A1298C according to Benjamin Lynch, says its bad to have both +/- and one needs Methyl Folic Acid
MTRR A66G +/+ Recommends Methyl-B12 (Been taking 1000mg) for a year now
MAO AR297R + ???
BHMT-01 + 02 + 04 + 08 are all +/- ???
ACHY -01 + 02 +19 are all +/- ???
I am concerned about MTHFR and MTRR as it seems they are specific to Neuropathies. I am currently taking these supplements for a year now as that is what I researched may help nerves In general. I don’t take folic acid at all.
I know being on a PPI can reduce absorption of vitamins and minerals. I do get my Vitamin D and B levels checked every 3 months and they are good. The information above is very conflicting as its saying I need to take methly-B12 and 5-methyl folate but having a COM V158++ is bad to have too much Methyl.
Important links to explain The Methylation Pathway
http://www.heartfixer.com/AMRI-Nutrigenomics.htm
http://www.snpedia.com/index.php/Yasko_Methylation
http://www.youtube.com/watch?v=QRHif...eature=related
http://www.knowyourgenetics.com/The%...20Pathway.html