A little off the subject, but since Aceyl-L-Carnitine is often taken with Lipoic Acid (and often not), I thought I'd throw this in. I bought some 1,000 mg capsules from Vitamin World (aka Puritan's Pride), and there's no way I can take these monster capsules (with or without food) without getting acid getting acid reflux. I'm usually pretty tolerant of stuff(I take 900mg of ALA at once), but no one will talk me into trying this stuff again even in smaller doses. That's my personal experience, but if you feel you would like to try it, good luck. LOL