I take tizanidine at bedtime. My spasms had been waking me up at night and the tizanidine has worked well. It has the additional effect of knocking me out within half an hour so I have to plan to have everything done before taking the pill. During the daytime, I use Ketamine cream on my tight muscles. It helps a little. Warm water also helps to the point I never want to come out of the pool. Epsom salt baths also help.