Conductor, Paula was seriously interested in the effects of neurotransmitters, and you probably have read posts of hers that may contain information relating to this. I know from personal experience that anticholinergics change the neurotransmitter balance enough to give better more fluid movement than dopamine alone. My belief is that there is a delicate balance that is needed, and that if one is affected they all are. Having said that you present a very interesting case, and I am looking forward to hearing more, especially as I am one of that number of people who are dopamine responsive, but have a negative scan. Your theory fits neatly with that, but I still have this idea, that the neurological tightrope is dependent on this fine balance, so that everything harmonizes to produce smooth fluid fast movement. That they are all interdependent. i would love to know whether their have been any animal studies on norepinephrine alone, and how those differ from dopamine alone.

Posting as much to keep this up at the top as anything, and looking forward to more........