You might. In the beginning, people who start supplements may be filling a "void" that was long standing.

Once that is fixed, then just keeping a bit of them going into those enzyme systems may be enough.

There just isn't much research on this subject, because it would cost lots of money, to guide people.

Omega-3's are essential, meaning we need to have them in the diet or supplemented. But other things like carnitine, CoQ-10, lipoic acid, are actually made by our bodies. (statins will deplete CoQ-10 over time because of their chemistry).

If something a person is taking is a depleter...then adding the depleted nutrient back in is important.

Ethambutol for example depletes copper and zinc. So taking those in a multivitamin or in the form of OptiZinc may be necessary over time. I don't recall your other drugs. Many antibiotics though over time deplete B-complex, inositol, Vit K
Biotin. But not all of them do this equally.
B12 I think you need daily. I wouldn't stop that.
Taking acid blocking drugs reduce nutrient status of
calcium
zinc
magnesium
B12
folate
iron. And those are only the ones we know about so far.