You mean alkaseltzer the cold medicine???

I can't really find anything that sets mine off. I ate good that day. Most nights I can put the neuragen cream on it, or stick my feet out of covers, or sleep on couch for awhile, etc but then there are nights like last night where nothing helps, even the air touching them hurts. Cold, freezing cold then hot, blazing hot.

I have not ordered magnesium lotion yet.