Thread: Hey MrsD :)
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Old 05-01-2007, 05:07 AM
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mrsD mrsD is offline
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Join Date: Aug 2006
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mrsD mrsD is offline
Wisest Elder Ever
mrsD's Avatar
 
Join Date: Aug 2006
Location: Great Lakes
Posts: 33,508
15 yr Member
Lightbulb Okay, I understand now...

But I don't have a real answer tho.

The adrenal glands like other endocrine glands in the body is run by the
pituitary/hypothalamus using a feedback loop.

This means that when hormone levels are low, the pituitary releases signaling
hormones to tell the end gland to make more, and the reverse.
Thyroid/sex hormones/adrenal work this way.

When you give Prednisone or other steroids, you shut down the feedback loop and the adrenals are stimulated less. Since Prednisone is only ONE of the types of hormones made, then when the adrenals shut down, other substances become less as well. This may upset the balance and somehow affect the
nerves.

Also steroids stimulate glucose manufacture in the liver, this raises blood glucose levels and we know that this is a prediabetic state, and affects glucose metabolism in the nerves. (sorbitol pathways damage the nerves)

There may be more than one effect when steroids are used, I think.
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