I was having problems with my dosage too. At first I thought I was taking too much, but because I was getting worse after three to four hours, I changed my dose (with my doctors permission) to every four hours instead of one pill (60 mg) every eight hours. I still have weakness, but not as bad. I even tried a dose every three hours, but I became weaker. So, I went back to taking Mestinon every four hours.