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In Remembrance
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Join Date: Aug 2006
Posts: 3,772
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In Remembrance
Join Date: Aug 2006
Posts: 3,772
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So, in a very large nutshell....
Quite a cozy little dust bunny under the bed here, isn't it? Dopamine is our bottom line. It is made from tyrosine which is made from phenylalanine with the help of tyrosine hydroxylase, all presumably powered by mitochondria. Further, if we need a shot of adrenaline or noradrenaline we cannabilize the material from the dopamine. A lot of things here all leading to a shortage, seems to me.
Quote:
Originally Posted by Conductor71
Sure thing. Funny, any other time I post the link but was too tired. Unfortunately, it is not free full text.
A possible pathophysiological role of tyrosine hydroxylase in Parkinson's disease suggested by postmortem brain biochemistry: a contribution for the special 70th birthday symposium in honor of Prof. Peter Riederer.
Nakashima A, Ota A, Kaneko YS, Mori K, Nagasaki H, Nagatsu T.
Source
Department of Physiology, Fujita Health University School of Medicine, Toyoake, |
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000.
Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well.
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