Quote:
Originally Posted by debter
I just went to my foot doctor because I had a very bad achilles problem and severe leg and foot cramping which i think was brought on by taking budesonide and a ciprofloxin eye ointment. I stopped both those medications and my other dr then put me on apriso for microscopic collitis. started that this last monday and on the same day while at the foot dr we also discussed the numbness in the balls of my feet. I had been there before for that problem. he thinks it is neuropathy even tho i had a nerve test for that. he said it is missed because it is not advanced enough. the foot dr gave me naprosyn. Anyway after 4 days of apriso and naprosyn my feet are burning, numb, painful, hard to walk. called the gastor dr this am but they are closed until monday. I think i should quit the apriso, does anyone know if that causes neuropathy to get worse? and continue the naprosyn. also, i think the neuropathy was actually better with the budesonide. what do you think? my foot dr gave me a list of supplements for neuropathy..vit c 1000mg, alpha-lipoid acid 100mg, n-acetyl-cystine 600mg, l-caritine 500mg, selinium 200mg, b-complex 100mg, b-12.
|
This is a paper on colitis and PN occurring together:
http://www.ncbi.nlm.nih.gov/pubmed/17715640
Quote:
Acta Gastroenterol Belg. 2007 Apr-Jun;70(2):226-30.
Acute motor sensory polyneuropathy (AMSAN) complicating active ulcerative colitis with a patchy distribution.
Zezos P, Mpoumponaris A, Koutsopetras P, Vounotrypidis P, Molyvas E, Vadikolias K, Moschos I, Kouklakis G.
Source
Department of Gastroenterology and Hepatology, 424 Military General Hospital, Thessaloniki, Greece. zezosp@hol.gr
Abstract
We report a case of acute motor and sensory neuropathy during a flare of ulcerative colitis. A 28-year-old male presented with a flare of distal ulcerative colitis despite treatment with mesalamine enemas and suppositories simultaneously with rapidly deteriorating weakness and needle sensation in both legs. Neurological assessment showed axonal sensorimotor polyneuropathy affecting mainly the lower limbs and to a lesser extent the upper limbs. Colonoscopy revealed moderately to severe active ulcerative colitis with a patchy distribution involving the rectum and the right colon. Vitamin and folic acid levels were normal. Virological, immunological and other laboratory tests were negative except for positive anti-ganglioside antibodies (anti-GM1). Ulcerative colitis and polyneuropathy improved when patient was treated with immunosuppressive therapy (corticosteroids, immunoglobulin and azathioprine). Peripheral polyneuropathy is a rare extraintestinal manifestation of ulcerative colitis and it is probably associated with an autoimmune pathogenetic mechanism.
PMID:
17715640
[PubMed - indexed for MEDLINE]
|
Now, I'd like to ask if you if only used one tube or so of the ciprofloxacin opth ointment?
This ointment has 3 milligrams of ciprofloxacin in a gram of base. The average tube is 3.5 grams.
In comparison, the smallest oral dose is 250mg twice a day.
This is a bit of reality check...and continues below.
This link gives blood levels measured in patients using the ophthalmic ointment:
http://www.alcon.ca/pdf/Product_phar...iloxan_eng.pdf
Typical absorption into the blood stream was 1.5 to 2.5 NANOgrams per ml of blood measured.
The typical blood level of Cipro 250mg is 1200 NANOgrams per ml.
What is a nanogram?
A nanogram (ng) is, therefore, 10-9g or one
billionth of a gram. This can be written as a unit in the 9th decimal place: 0.000000001g.
It is unlikely therefore, that an ophthalmic ointment would deliver much Cipro to your body, or enough to create a systemic neuropathy. It is significant for allergic reactions however.
If a neuropathy were to begin I would expect it in or around the eye first.
But also I'd like to know how much or often you used that ointment. Most people only use a product like this for temporary infections, or surgery around the eye.
I have a thread here on drugs known to cause PN...
http://neurotalk.psychcentral.com/thread122889.html
The PN could be related to your colitis. Crohn's patients sometimes get an inflammatory arthritis with their pathology.
It is a similar autoimmune effect.
The link I gave you first on this post has treatment options for colitis that has other manifestations....and that is to use other immune suppressing drugs.
Some people just cannot tolerate mesalamine products. So yes, to ask your doctor and explain your potential side effects.
__________________
All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
************************************
.
Weezie looking at petunias 8.25.2017
****************************
These forums are for mutual support and information sharing only. The forums are not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. Always consult your doctor before trying anything you read here.