Thanks, Glenn, for a detailed explanation as per your usual. I wanted to reply as I was disturbed by Hannah's question, it didn't seem like she was given a serious skin biopsy. Mine was as you described, but then it was done at Hopkins, the third one was at the upper thigh near the hip, but my legs are very long so this may have affected the sites. Ankle and just above the knee were the others. All showed deterioration, but in a clearly length dependent and progressive pattern. Information from one site only would seem very incomplete.